Development and external validation of Indian population-specific Garbhini-GA2 model for estimating gestational age in second and third trimesters

https://doi.org/10.1016/j.lansea.2024.100362

Authors

Veerendra P. Gadekar , Nikhita Damaraju , Ashley Xavier , Shambo Basu Thakur , Ramya Vijayram , Bapu Koundinya Desiraju , Sumit Misra , Shinjini Bhatnagar , Nitya Wadhwa , Uma Chandra Mouli Natchu , Bhabatosh Das , Pallavi S. Kshetrapal , Shailaja Sopory , Ramachandran Thiruvengadam , Sumit Misra , Dharmendra Sharma , Kanika Sachdeva , Amanpreet Singh , Balakrish G. Nair , Satyajit Rath , Vineeta Bal , Alka Sharma , Sunita Sharma , Umesh Mehta , Brahmdeep Sindhu , Pratima Mittal , Rekha Bharti , Harish Chellani , Rani Gera , Jyotsna Suri , Pradeep Debata , Sugandha Arya , Arindam Maitra , Tushar K. Maiti , Dinakar M. Salunke , Nikhil Tandon , Yashdeep Gupta , Alpesh Goyal , Smriti Hari , Aparna Sharma K , Anubhuti Rana , Siddarth Ramji , Anju Garg , Ashok Khurana , Reva Tripathi , Rakesh Gupta , Himanshu Sinha , Raghunathan Rengaswamy , Partha P. Majumder , Vineeta Bal , Pratima Mittal , Uma Chandra Mouli Natchu , Harish Chellani , Ramachandran Thiruvengadam , Nitya Wadhwa , Ashok Khurana , Swati Rathore , Anuja Abraham , Raghunathan Rengaswamy , Santosh Benjamin , Anne George Cherian , Shinjini Bhatnagar , Ramachandran Thiruvengadam , Himanshu Sinha

Published In

The Lancet Regional Health - Southeast Asia, vol. 25, p. 100362

Tags

Antenatal Care Hadlock Formula

A large proportion of pregnant women in lower and middle-income countries (LMIC) seek their first antenatal care after 14 weeks of gestation. While the last menstrual period (LMP) is still the most prevalent method of determining gestational age (GA), ultrasound-based foetal biometry is considered more accurate in the second and third trimesters. In LMIC settings, the Hadlock formula, originally developed using data from a small Caucasian population, is widely used for estimating GA and foetal weight worldwide as the pre-programmed formula in ultrasound machines. This approach can lead to inaccuracies when estimating GA in a diverse population. Therefore, this study aimed to develop a population-specific model for estimating GA in the late trimesters that was as accurate as the GA estimation in the first trimester, using data from GARBH-Ini, a pregnancy cohort in a North Indian district hospital, and subsequently validate the model in an independent cohort in South India.