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Constraint-Based Modelling

CAMP: The perfect bacterial matchmaker

Blogs

Lovers, enemies, friends aren’t the relationships confined to human or animal societies. Tiny beings like bacteria also react to different bacteria in their vicinity, and their growth and survival depend on the kind of …

Tags: Genome-scale metabolic models, Constraint-based modelling, Metabolic engineering

Two-species community design of lactic acid bacteria for optimal production of lactate

Publications

Microbial communities that metabolise pentose and hexose sugars are useful in producing high-value chemicals, resulting in the effective conversion of raw materials to the product, a reduction in the production cost, and …

Tags: Systems biology, Constraint-based modelling

Deciphering the metabolic capabilities of Bifidobacteria using genome-scale metabolic models

Publications

Abstract Bifidobacteria, the initial colonisers of breastfed infant guts, are considered as the key commensals that promote a healthy gastrointestinal tract. However, little is known about the key metabolic differences …

Tags: bifidobacteria, constraint based modelling, AGORA

Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma

Publications

Retinoblastoma (RB) is a childhood eye cancer. Currently, chemotherapy, local therapy, and enucleation are the main ways in which these tumors are managed. The present work is the first study that uses constraint‐based …

Tags: systems biology, constraint-based modelling, metabolism

Systems-Level Modelling of Microbial Communities: Theory and Practice

Publications

Systems-Level Modelling of Microbial Communities: Theory and Practice introduces various aspects of modelling microbial communities and presents a detailed overview of the computational methods which have been developed …

Tags: systems biology, constraint-based modelling, network-based modelling

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